Punnonen R, Hori A, Okawada M, Kudoh R
Acta Obstet Gynecol Scand. 1984;63(4):299-302. doi: 10.3109/00016348409155520.
Three cases with metastasized choriocarcinoma are reported. The basic chemotherapeutic regimen was methotrexate and actinomycin D, combined with cyclophosphamide or vinblastine. Surgery was used in the treatment of both primary and metastatic lesions. The chief indications for hysterectomy arise when chemotherapy has obviously failed. Thoracotomy was performed for a pulmonary metastasis and nephrectomy for a metastasis of the kidney. Craniotomy was performed to control the brain hemorrhage. Aggressive multidrug chemotherapy is considered necessary as the primary treatment for high-risk cases of trophoblastic disease.
报告了3例转移性绒毛膜癌病例。基本化疗方案为甲氨蝶呤和放线菌素D，联合环磷酰胺或长春碱。手术用于治疗原发性和转移性病变。当化疗明显失败时，是子宫切除术的主要指征。对肺转移灶进行了开胸手术，对肾转移灶进行了肾切除术。进行了开颅手术以控制脑出血。积极的多药化疗被认为是滋养细胞疾病高危病例的主要治疗方法。
