Kovács G L, Szontágh L, Baláspiri L, Telegdy G
Acta Physiol Hung. 1984;63(1):83-4.
The effect of dipeptides was studied on naloxone-precipitated morphine withdrawal in the mouse. In accordance with previous data, s.c. treatment with Z-prolyl-D-leucine delayed the onset of withdrawal jumpings . Replacement of L-proline by L-glutamate or L-pyroglutamate resulted in dipeptides which were more potent in morphine withdrawal than was Z-prolyl-D-leucine.
研究了二肽对小鼠纳洛酮诱发的吗啡戒断反应的影响。与先前的数据一致，皮下注射Z-脯氨酰-D-亮氨酸可延迟戒断跳跃的发作。用L-谷氨酸或L-焦谷氨酸替代L-脯氨酸得到的二肽，在吗啡戒断方面比Z-脯氨酰-D-亮氨酸更有效。
