Lee K, Kubota T, Sawamara M, Kadowaki K, Kawamura E, Egawa S, Ishibashi A
Gan To Kagaku Ryoho. 1984 Jul;11(7):1444-9.
To elucidate the influence of methylprednisolone (MPL) on the antitumor effect of cis-diamminedichloroplatinum (II) (CDDP), experimental chemotherapy of CDDP with or without MPL was performed. A human breast carcinoma, MX-1 serially transplanted into nude mice was treated with CDDP in doses of 1.5 and 3.0 mg/kg in schedule of q4d X 3 ip. KKN-1, a syngeneic fibrosarcoma of BALB/c transplanted into BALB/c +/+ or BALB/c nu/nu mice, was treated with CDDP in doses of 3 or 6 mg/kg in schedule of qd X 1 ip. In the combination of MPL, 20 mg of MPL per kg was administered ip three hours before CDDP treatment. Although some decrease of antitumor effect of CDDP was observed by combination with MPL, no statistically significant difference was noted between group given CDDP alone and those given CDDP plus MPL. It was concluded that the use of MPL is reasonable to prevent the severe emesis caused by CDDP when this adverse effect is resistant to other antiemetic agents.
为阐明甲泼尼龙（MPL）对顺二氯二氨铂（II）（CDDP）抗肿瘤作用的影响，进行了有或无MPL的CDDP实验性化疗。将人乳腺癌MX - 1连续接种到裸鼠体内，以1.5和3.0 mg/kg的剂量按每4天1次、共3次腹腔注射CDDP进行治疗。将BALB/c同基因纤维肉瘤KKN - 1接种到BALB/c +/+或BALB/c nu/nu小鼠体内，以3或6 mg/kg的剂量按每天1次腹腔注射CDDP进行治疗。在联合使用MPL的情况下，在CDDP治疗前3小时腹腔注射每千克20 mg的MPL。虽然观察到与MPL联合使用时CDDP的抗肿瘤作用有所降低，但单独给予CDDP的组与给予CDDP加MPL的组之间未发现统计学上的显著差异。得出的结论是，当这种不良反应对其他止吐药耐药时，使用MPL来预防CDDP引起的严重呕吐是合理的。
