Apaja-Sarkkinen M, Alavaikko M
Eur J Cancer Clin Oncol. 1984 Jun;20(6):735-41. doi: 10.1016/0277-5379(84)90209-8.
In a retrospective reclassification of 148 non-Hodgkin's lymphomas the reproducibility of the Lukes-Collins classification used was tested by comparing a joint diagnosis with that of each author separately. Thirty-six percent of the lymphoma cases were follicular center cell lymphomas, the figure being clearly lower than that of materials published previously. The relatively high portions of small lymphocytic and mycosis fungoides lymphomas (20 and 10% respectively) were also deviant findings in comparison to formerly published retrospective materials. In this reproducibility study the cases of disagreement were usually proved to have happened within lymphoma groups with an equivalent prognosis. An exception was the relatively high disagreement rate between the subclasses of small lymphocytic and small non-cleaved lymphomas, and this represents the most important finding clinicopathologically. The results of the study indicate that the Lukes-Collins classification as such does not cover the whole spectrum of non-Hodgkin's lymphomas. The studies published already give some clues as to the fact that distribution and cell types of non-Hodgkin's lymphomas vary in different areas of the world.
在对148例非霍奇金淋巴瘤进行回顾性重新分类时，通过将联合诊断结果与每位作者单独的诊断结果进行比较，检验了所采用的卢克斯-柯林斯分类法的可重复性。36%的淋巴瘤病例为滤泡中心细胞淋巴瘤，这一数字明显低于先前发表资料中的数据。与先前发表的回顾性资料相比，小淋巴细胞性淋巴瘤和蕈样霉菌病淋巴瘤所占比例相对较高（分别为20%和10%），这也是异常发现。在这项可重复性研究中，通常证明分歧病例发生在预后相当的淋巴瘤组内。小淋巴细胞性淋巴瘤和小无裂细胞淋巴瘤亚类之间的分歧率相对较高是个例外，这是临床病理方面最重要的发现。研究结果表明，卢克斯-柯林斯分类法本身并未涵盖非霍奇金淋巴瘤的整个范围。已发表的研究已经提供了一些线索，表明非霍奇金淋巴瘤的分布和细胞类型在世界不同地区有所不同。
