Vogler W R, Whigham E A, Somberg L B, Long R C, Winton E F
Exp Hematol. 1984 Aug;12(7):569-74.
Alkyl-lysophospholipids are analogues of 2-lysophosphatidylcholine which have been reported to have selective antitumor activity. A survey of the in vitro activity of racemic 1-octadecyl-2-methoxy-glycero-3 phosphorylcholine on in vitro clonogenicity in soft agar and tritiated thymidine incorporation was conducted on bone marrow specimens from a series of patients with acute myelogenous leukemia (AML) and chronic myelocytic leukemia (CML) and hematologically normal individuals. A dose- and time-dependent inhibition of colony formation and thymidine incorporation was observed in the normal and leukemic specimens. No selective effect of the compound could be demonstrated under the conditions employed in these studies.
烷基溶血磷脂是2-溶血磷脂酰胆碱的类似物，据报道具有选择性抗肿瘤活性。对一系列急性髓性白血病（AML）、慢性粒细胞白血病（CML）患者及血液学正常个体的骨髓标本，进行了外消旋1-十八烷基-2-甲氧基甘油-3-磷酸胆碱对软琼脂中体外克隆形成能力及氚标记胸腺嘧啶核苷掺入影响的体外活性研究。在正常和白血病标本中均观察到集落形成和胸腺嘧啶核苷掺入呈剂量和时间依赖性抑制。在这些研究采用的条件下，未证实该化合物有选择性作用。
