顺铂对体外培养的胚胎癌细胞系的作用。

Effects of cis-platinum on embryonal carcinoma cell lines in vitro.

作者信息

Oosterhuis J W, Andrews P W, Knowles B B, Damjanov I

出版信息

Int J Cancer. 1984 Jul 15;34(1):133-9. doi: 10.1002/ijc.2910340123.

Abstract

Human and mouse embryonal carcinoma (EC) cells lines were compared with several cell lines of a more differentiated phenotype for their relative sensitivities to the cytotoxic effects of cis-platinum (cis-diamine-dichloroplatinum; CDDP); EC lines were among the most sensitive. Furthermore, several markers of EC cell differentiation were not induced by CDDP, irrespective of the concentration of the drug used. These data provide an explanation for the relative sensitivity of the EC cells in non-seminomatous germ-cell tumors to cis-platinum therapy.

摘要

将人及小鼠胚胎癌（EC）细胞系与几种具有更分化表型的细胞系进行比较，以研究它们对顺铂（顺二氨二氯铂；CDDP）细胞毒性作用的相对敏感性；EC细胞系是最敏感的细胞系之一。此外，无论所用药物浓度如何，CDDP均未诱导EC细胞分化的几种标志物。这些数据解释了非精原性生殖细胞肿瘤中的EC细胞对顺铂治疗相对敏感的原因。