Parvez H, Parvez S, Abiko Y
Jpn J Pharmacol. 1984 Feb;34(2):171-6. doi: 10.1254/jjp.34.171.
The activity of phenylethanolamine-N-methyltransferase (PNMT) was studied in the hypothalamus, hypophysis, striatum and the rest of the brain during the four different phases of the oestrous cycle of the rat. The oestrous phase was marked by high level of enzyme activity in all the regions except the hypophysis. The hypophysis showed maximum increase in activity at the metoestrous phase of the oestrous cycle. Chronic treatment of rats with dexamethasone for 10 days led to decreased level of PNMT activity in the hypophysis, hypothalamus and the rest of brain. These decreases were important in the hypothalamus and the hypophysis which represented only 25 and 20% of the control activity after dexamethasone administration.
在大鼠动情周期的四个不同阶段，研究了苯乙醇胺 -N-甲基转移酶（PNMT）在下丘脑、垂体、纹状体及大脑其他部位的活性。动情期的特点是除垂体外，所有区域的酶活性水平都很高。垂体在动情周期的间情期活性增加最多。用 dexamethasone 对大鼠进行 10 天的慢性治疗导致垂体、下丘脑及大脑其他部位的 PNMT 活性水平降低。在下丘脑和垂体中，这些降低很显著，给予 dexamethasone 后，它们的活性仅为对照活性的 25%和 20%。
