蜱瘫痪类毒素：一种针对全环硬蜱毒素的有效免疫制剂。

Tick-paralysis toxoid: an effective immunizing agent against the toxin of Ixodes holocyclus.

作者信息

Stone B F, Neish A L

出版信息

Aust J Exp Biol Med Sci. 1984 Apr;62 ( Pt 2):189-91. doi: 10.1038/icb.1984.18.

DOI:10.1038/icb.1984.18

Abstract

Glutaraldehyde treatment of the toxin of the Australian paralysis tick Ixodes holocyclus produced a potent, immunogenic toxoid. Three subcutaneous injections (2 to 4 weeks apart) into rabbits produced very high antitoxin titres in their serum, although circulating antitoxin titres declined in the absence of stimulation. Twenty weeks later, immunized rabbits were unaffected by lethal doses of toxin injected subcutaneously.

摘要

用戊二醛处理澳大利亚麻痹蜱全环硬蜱的毒素，产生了一种高效、具有免疫原性的类毒素。对兔子进行三次皮下注射（间隔2至4周）后，其血清中产生了非常高的抗毒素滴度，不过在没有刺激的情况下，循环抗毒素滴度会下降。二十周后，免疫的兔子对皮下注射的致死剂量毒素没有反应。