阿扑吗啡对多巴胺超敏大鼠亮度辨别记忆保持的影响。

Effect of apomorphine on retention of a brightness discrimination in dopamine supersensitive rats.

作者信息

Honza R, Schumacher H, Klauck A, Grecksch G, Matthies H

出版信息

Behav Neural Biol. 1984 May;41(1):23-9. doi: 10.1016/s0163-1047(84)90680-0.

Abstract

Apomorphine is known to improve the retention performance of a brightness discrimination task after post-training intrahippocampal application to rats. The present study shows that the retention performance of dopamine supersensitive rats was improved by a low dose of apomorphine which was still ineffective in control animals. Dopamine supersensitivity by itself had no effect on acquisition and retention parameters of brightness discrimination. The result further supports the assumption that dopamine receptors in rat hippocampus can modulate the formation of memory.

摘要

已知阿扑吗啡在训练后对大鼠海马内给药可改善亮度辨别任务的记忆保持表现。本研究表明，低剂量的阿扑吗啡可改善多巴胺超敏大鼠的记忆保持表现，而该剂量对对照动物仍无效果。多巴胺超敏本身对亮度辨别任务的习得和记忆保持参数没有影响。该结果进一步支持了大鼠海马中的多巴胺受体可调节记忆形成这一假设。