二氯二茂钛治疗艾氏腹水瘤的免疫反应
Immunologic response to the treatment of Ehrlich ascites tumor with titanocene dichloride.
作者信息
Köpf-Maier P, Hesse A
出版信息
J Cancer Res Clin Oncol. 1984;108(2):254-5. doi: 10.1007/BF00402480.
Abstract
After treatment of mice bearing Ehrlich ascites tumor (EAT) with titanocene dichloride, it could be shown (a) that all cured animals were able to reject EAT cells implanted subsequently and (b) that in the serum of these animals the contents of gamma-globulins was markedly increased, whereas after treatment with cis-platinum both the ability to reject EAT cells and the increase of gamma-globulins were less pronounced. It is supposed that the observed increase of gamma-globulins is due to a stimulated production of antibodies against EAT.
摘要
用二氯二茂钛处理荷艾氏腹水瘤（EAT）的小鼠后，可以发现：（a）所有治愈的动物都能够排斥随后植入的EAT细胞；（b）这些动物血清中的γ-球蛋白含量显著增加，而用顺铂处理后，排斥EAT细胞的能力和γ-球蛋白的增加都不太明显。据推测，观察到的γ-球蛋白增加是由于针对EAT的抗体产生受到刺激。
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