Leedy M G
Psychoneuroendocrinology. 1984;9(2):189-96. doi: 10.1016/0306-4530(84)90038-6.
The effects of small lesions in the preoptic area (POA) of female rats on estrous cycles, LH responsiveness, and receptivity were studied. Regularly cycling rats received lesions confined to either the periventricular portion or the ventral portion of the rostral preoptic area, or a combination of these two sites. Nine animals showed persistent vaginal cornification (PVC) following lesion placement. All of these had lesions in the periventricular preoptic area. In contrast, five of six animals which showed repeated periods of pseudopregnancy (RPP) had lesions in the most ventral portion of the preoptic area. Lesions which damaged both the periventricular POA and the ventral POA gave mixed results. Following ovariectomy and estrogen and progesterone stimulation, the RPP animals had higher levels of LH 6 hr after the P injection than did the control animals or PVC animals. In three different tests for female sexual behavior--with estrogen alone, estrogen plus progesterone, and low estrogen priming and repetitive sexual stimulation--the PVC animals had consistently lower receptivity than the controls. The RPP animals were more receptive than the controls in all but the estrogen plus progesterone tests. The decreased levels of receptivity of the PVC animals could be related to a disruption of the LHRH system, while the RPP group responses could reflect a hypersensitivity of remaining neurons to estrogen.
研究了雌性大鼠视前区（POA）小损伤对发情周期、促黄体生成素（LH）反应性和接受性的影响。规律发情的大鼠接受局限于视前区头端室周部分或腹侧部分的损伤，或这两个部位的联合损伤。9只动物在损伤后出现持续阴道角化（PVC）。所有这些动物的室周视前区都有损伤。相比之下，6只出现反复假孕周期（RPP）的动物中有5只在视前区最腹侧部分有损伤。同时损伤室周POA和腹侧POA的结果不一。卵巢切除并给予雌激素和孕激素刺激后，RPP动物在注射孕激素后6小时的LH水平高于对照动物或PVC动物。在三种不同的雌性性行为测试中——单独使用雌激素、雌激素加孕激素以及低剂量雌激素预处理和重复性刺激——PVC动物的接受性始终低于对照动物。除雌激素加孕激素测试外，RPP动物在所有测试中的接受性均高于对照动物。PVC动物接受性降低可能与促性腺激素释放激素（LHRH）系统紊乱有关，而RPP组的反应可能反映了剩余神经元对雌激素的超敏反应。
