Lundh H, Nilsson O, Rosén I
Neurology. 1984 Oct;34(10):1324-30. doi: 10.1212/wnl.34.10.1324.
We used a new drug, 3,4-diaminopyridine, to treat five patients with the Lambert-Eaton syndrome, one with a carcinoma and four cryptogenic. The effects of intravenous, oral, and rectal administration were evaluated clinically and electrophysiologically after single doses and during continuous treatment for up to 21 months. 3,4-Diaminopyridine effectively ameliorated the neuromuscular and autonomic nervous system disorders without severe side effects. Anticholinesterase drugs strongly potentiated the benefit of 3,4-diaminopyridine.
我们使用一种新药3,4 - 二氨基吡啶治疗5例兰伯特 - 伊顿综合征患者，其中1例患有癌症，4例病因不明。在单次给药后以及长达21个月的持续治疗期间，对静脉注射、口服和直肠给药的效果进行了临床和电生理评估。3,4 - 二氨基吡啶有效改善了神经肌肉和自主神经系统紊乱，且无严重副作用。抗胆碱酯酶药物显著增强了3,4 - 二氨基吡啶的疗效。
