The effects of intravenous miconazole on fungal keratitis.

Two patients, a 44-year-old man and a 53-year-old man, with fungal keratitis were successfully treated with intravenously infused miconazole, a synthetic imidazole derivative. In these cases healing and regression of the corneal ulcer began four or five days after initiation of miconazole treatment. The clinical evidence of corneal infection disappeared completely after four weeks and visual acuities improved markedly (from 20/500 to 20/20 in Case 1 and from 20/400 to 20/40 in Case 2). Aside from a transient increase of serum triglycerides and beta-lipoproteins, the drug appeared to be well tolerated.