百日咳毒素对豚鼠离体回肠中去甲吗啡依赖性以及去甲吗啡和可乐定急性抑制作用的影响。
Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.
作者信息
Tucker J F
出版信息
Br J Pharmacol. 1984 Oct;83(2):326-8. doi: 10.1111/j.1476-5381.1984.tb16491.x.
Abstract
In guinea-pig isolated ileum from animals pretreated with Pertussis toxin, the acute inhibitory effects of normorphine and clonidine on electrically induced contractions were markedly attenuated whilst responses to acetylcholine and electrical stimulation were unaltered. Pertussis toxin treatment also reduced naloxone-precipitated withdrawal contractures in normorphine-dependent tissues. These results suggest that the acute and chronic effects of normorphine are mediated by the same mechanism, namely that of adenylate cyclase inhibition.
摘要
在经百日咳毒素预处理的豚鼠离体回肠中，去甲吗啡和可乐定对电诱导收缩的急性抑制作用明显减弱，而对乙酰胆碱和电刺激的反应未改变。百日咳毒素处理还减少了去甲吗啡依赖组织中纳洛酮诱发的戒断挛缩。这些结果表明，去甲吗啡的急性和慢性作用是由相同机制介导的，即腺苷酸环化酶抑制机制。
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本文引用的文献
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Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.胰岛激活蛋白通过对一种膜蛋白进行ADP核糖基化作用直接修饰膜腺苷酸环化酶系统。
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Pertussis vaccine inhibits the chronic but not acute action of normorphine on the myenteric plexus of guinea-pig ileum.百日咳疫苗可抑制去甲吗啡对豚鼠回肠肌间神经丛的慢性作用，但不能抑制其急性作用。
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Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.百日咳毒素降低神经母细胞瘤x胶质瘤杂交细胞系中的阿片受体结合和腺苷酸抑制作用。
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