心房利钠因子释放的细胞机制。

Cellular mechanism of release of atrial natriuretic factor.

作者信息

Sonnenberg H, Veress A T

出版信息

Biochem Biophys Res Commun. 1984 Oct 30;124(2):443-9. doi: 10.1016/0006-291x(84)91573-0.

PMID:6541909

Abstract

Tissue extracts of rat heart atria contain a family of peptides with natriuretic and vasorelaxant properties. We have shown previously that this "atrial natriuretic factor" may be released in vitro from incubated atria by muscarinic cholinergic stimulation. Experiments reported here demonstrate that incubation with adrenalin or arginine vasopressin, but not with deamino-8-D-arginine vasopressin, also results in liberation of atrial natriuretic factor. Since the effective agonists have in common activation of the cellular polyphosphoinositide system with consequent production of inositol triphosphate, we suggest that inositol triphosphate is the second messenger of stimulus-secretion coupling in atrial cells.

摘要

大鼠心房的组织提取物含有一族具有利钠和血管舒张特性的肽。我们之前已经表明，这种“心房利钠因子”在体外可通过毒蕈碱胆碱能刺激从孵育的心房中释放出来。此处报道的实验表明，与肾上腺素或精氨酸加压素一起孵育可导致心房利钠因子的释放，但与脱氨基 - 8 - D - 精氨酸加压素一起孵育则不会。由于有效的激动剂共同作用于细胞多磷酸肌醇系统，从而产生肌醇三磷酸，我们认为肌醇三磷酸是心房细胞中刺激 - 分泌偶联的第二信使。