Müldner H, Zöller M
Arzneimittelforschung. 1984;34(8):918-20.
In 6 women with depressive symptoms aged 55-65 years the effect on the excretion of urinary metabolits of noradrenaline and dopamine was measured after a monotherapy with the active hypericine complex (Psychotonin M). In all patients there was a significant increase in 3-methoxy-4-hydroxyphenylglucol which is considered an expression of a beginning antidepressive reaction. With the same patients supplemented with further 9 cases the clinical influence on the depression was measured during a period of 4-6 weeks, with the rating-scales SCAG (Clinical assessment geriatric scale) and DSI (Depression Status Inventory) there was shown a quantitative improvement of the items anxiety, dysphoric mood, loss of interest, hypersomnia, anorexia, depression regularly worse in the morning, insomnia, obstipation, psychomotoric retardation and feeling of worthlessness.
在6名年龄在55至65岁之间有抑郁症状的女性中，测量了使用活性金丝桃素复合物（Psychotonin M）单一疗法后去甲肾上腺素和多巴胺的尿代谢产物排泄情况。在所有患者中，3-甲氧基-4-羟基苯乙二醇均显著增加，这被认为是开始出现抗抑郁反应的一种表现。在这6名患者基础上又补充了9例患者，在4至6周的时间内测量了对抑郁症的临床影响，使用SCAG（老年临床评估量表）和DSI（抑郁状态量表）评分量表显示，焦虑、烦躁情绪、兴趣丧失、嗜睡、厌食、晨起抑郁加重、失眠、便秘、精神运动迟缓及无价值感等项目有定量改善。
