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[镇痛药和精神药物的成瘾可能性]

[Potential for dependence of analgesics and psychopharmaceuticals].

作者信息

Hoffmeister F

出版信息

Arzneimittelforschung. 1984;34(9A):1096-107.

PMID:6541933
Abstract

The dependence liability of analgesic and psychotropic drugs as assessed in animal experiments is described. It is demonstrated that the abuse liability of a given drug does not only depend on its pharmacological or psychopharmacological profile of actions. The abuse liability of a drug is, however, greatly influenced by environmental variables, motivation to self-administration of a drug as well as previous drug exposure. Correlations between dependent behavior of animals and dependent behavior of men are discussed.

摘要

描述了在动物实验中评估的镇痛和精神药物的依赖性。结果表明,一种给定药物的滥用倾向不仅取决于其药理或精神药理作用特征。然而,药物的滥用倾向在很大程度上受到环境变量、自我给药的动机以及先前药物暴露的影响。讨论了动物的依赖行为与人类的依赖行为之间的相关性。

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Drug interaction in the field of analgesic drugs.镇痛药领域的药物相互作用。
Proc R Soc Med. 1965 Nov;58(11 Part 2):978-83. doi: 10.1177/003591576505811P207.

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