Hoffmeister F
Arzneimittelforschung. 1984;34(9A):1096-107.
The dependence liability of analgesic and psychotropic drugs as assessed in animal experiments is described. It is demonstrated that the abuse liability of a given drug does not only depend on its pharmacological or psychopharmacological profile of actions. The abuse liability of a drug is, however, greatly influenced by environmental variables, motivation to self-administration of a drug as well as previous drug exposure. Correlations between dependent behavior of animals and dependent behavior of men are discussed.
描述了在动物实验中评估的镇痛和精神药物的依赖性。结果表明,一种给定药物的滥用倾向不仅取决于其药理或精神药理作用特征。然而,药物的滥用倾向在很大程度上受到环境变量、自我给药的动机以及先前药物暴露的影响。讨论了动物的依赖行为与人类的依赖行为之间的相关性。