足月新生儿纤溶酶原的生理激活

Physiological activation of plasminogen in full term newborn infants.

作者信息

Hilali M M, Gilliver B E

出版信息

J Clin Pathol. 1984 Nov;37(11):1264-7. doi: 10.1136/jcp.37.11.1264.

DOI:10.1136/jcp.37.11.1264

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498995/

Abstract

Plasminogen in full term newborn infants has been measured by functional and immunological assays. Plasminogen functional activity and antigen concentration in newborn infants were about 44% and 48% of adult values respectively. Physiological activation kinetics of plasminogen in undiluted plasma at pH 7.4 and 37 degrees C using various concentrations of streptokinase and urokinase showed no significant difference in the rate of plasmin generation between plasminogen from newborn infants and adult plasminogen. These findings dispute the suggested existence of functional anomalies in plasminogen from full term newborn infants.

摘要

已通过功能测定法和免疫测定法对足月新生儿的纤溶酶原进行了测量。新生儿的纤溶酶原功能活性和抗原浓度分别约为成人值的44%和48%。在pH 7.4和37摄氏度下，使用不同浓度的链激酶和尿激酶对未稀释血浆中的纤溶酶原进行生理激活动力学研究，结果显示新生儿纤溶酶原和成人纤溶酶原在纤溶酶生成速率上无显著差异。这些发现对足月新生儿纤溶酶原存在功能异常的说法提出了质疑。

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