Mirchev H
Vutr Boles. 1978;17(2):89-92.
Lesions of the parenchymal organs, not described so far, were found in two males and two females with acute acetone intoxication, besides the well known morbid changes in the gastrointestinal tract and ZNS, regardless the energetic hepato--and nephroprotective treatment. In all patients (one of them inhaled acetone vapours and the rest swallowed the poison per os) liver lesion is present with the corresponding clinical manifestations and changes in the laboratory liver indices. In two of the per orally intoxicated, renal lesion was also found, manifested in a milder degree. The state of the parenchymal organs is necessary to be followed up carefully in case of acute acetone intoxications and a timely treatment with hepato- and nephroprotective drugs in large doses to be applied: glucocorticoids, glucose and levulose solutions, cocarboxylase, lipovitan, vitamin "C", "B1", "B2", "B12", calcium gluconate.
在两名男性和两名女性急性丙酮中毒患者中，除了胃肠道和中枢神经系统已知的病变外，还发现了迄今为止未描述的实质器官病变，尽管进行了积极的肝和肾保护治疗。所有患者（其中一人吸入丙酮蒸气，其余经口吞服毒物）均有肝脏病变，并伴有相应的临床表现和肝脏实验室指标变化。在两名经口中毒患者中还发现了肾脏病变，程度较轻。对于急性丙酮中毒患者，必须仔细跟踪实质器官的状态，并及时大剂量应用肝和肾保护药物进行治疗：糖皮质激素、葡萄糖和果糖溶液、辅酶A、维他康复、维生素“C”、“B1”、“B2”、“B12”、葡萄糖酸钙。
