Tampier L, Quintanilla M E, Contreras S, Segovia-Requelme N, Mardones J
Alcohol Alcohol. 1984;19(3):203-9.
This paper is an inventory of some behavioural, biochemical and pharmacological similarities and differences between two inbred strains of Wistar rats differing in voluntary consumption of ethanol, namely: UChA and UChB with low and high preferences respectively for ethanol under conditions involving free choice between a 10% (v/v) ethanol solution and distilled water. The following strain differences were observed: ethanol consumption (UChA less than UChB); total water consumption (UChA less than UChB); solid food consumption (UChA greater than UChB); rate of recovery of ethanol label in expired CO2 (UChA less than UChB); oxidation of ethanol to acetaldehyde by brain homogenates (UChA greater than UChB); acetaldehyde disposal by brain homogenates (UChA less than UChB); ethanol (90 mmol/kg, i.p.) sleeping-time (UChA less than UChB); chronic and acute tolerance to ethanol (UChA developed it, whereas UChB did not); lethal doses of ethanol (UChA greater than UChB); recovery rate of the label of gluconate in expired CO2 (UChA less than UChB); recovery rate of the label of fructose in expired CO2 (UChA less than UChB); blood-glucose level after glucose (1 g/kg, i.p.) load (UChA less than UChB). No strain differences were observed in the rate of recovery in expired CO2 of the label of the following substrates: acetate, pyruvate, butyrate, citrate, ribose, glycerol, sorbitol, glucose and galactose.
本文对两种近交系Wistar大鼠在乙醇自愿摄入量上存在差异（即在10%（v/v）乙醇溶液和蒸馏水之间自由选择的条件下，UChA对乙醇偏好低，UChB对乙醇偏好高）的行为、生化和药理学方面的异同进行了总结。观察到以下品系差异：乙醇消耗量（UChA低于UChB）；总水消耗量（UChA低于UChB）；固体食物消耗量（UChA高于UChB）；呼出二氧化碳中乙醇标记物的回收率（UChA低于UChB）；脑匀浆将乙醇氧化为乙醛的能力（UChA高于UChB）；脑匀浆对乙醛的处理能力（UChA低于UChB）；乙醇（90 mmol/kg，腹腔注射）睡眠时间（UChA低于UChB）；对乙醇的慢性和急性耐受性（UChA产生耐受性，而UChB未产生）；乙醇致死剂量（UChA高于UChB）；呼出二氧化碳中葡萄糖酸盐标记物的回收率（UChA低于UChB）；呼出二氧化碳中果糖标记物的回收率（UChA低于UChB）；葡萄糖（1 g/kg，腹腔注射）负荷后血糖水平（UChA低于UChB）。在呼出二氧化碳中以下底物标记物的回收率方面未观察到品系差异：乙酸盐、丙酮酸盐、丁酸盐、柠檬酸盐、核糖、甘油、山梨醇、葡萄糖和半乳糖。
