大鼠分化肝细胞绝对体积的形态计量学研究。

Morphometric study on the absolute volume of differentiating hepatocytes in rats.

作者信息

Daimon T, David H, von Zglinicki T, Marx I

出版信息

Exp Pathol. 1984;26(3):141-9. doi: 10.1016/s0232-1513(84)80041-9.

Abstract

Quantitative changes in the mean absolute volume of rat hepatocytes during prenatal development were studied by light microscopic stereological methods. Combining these light microscopic measurements with electron microscopic relative volume (volume density) data (Daimon et al. 1982) enabled the evaluation of the mean absolute volumes of cytoplasmic organelles of fetuses and newborns. On the 15th day of gestation the mean absolute volume of hepatocytes was 1,523 +/- 10.7 microns3. After 3 days hepatocytes were enlarged 66.2% (2,531.5 +/- 108.2) and at birth 157.1% (3,915.6 +/- 190.8). The comparison of the absolute volume and the volume density of each cell organelle made possible the interpretation of much functional and morphometric data of the development of hepatocytes.

摘要

采用光学显微镜体视学方法研究了大鼠肝细胞在产前发育过程中平均绝对体积的定量变化。将这些光学显微镜测量结果与电子显微镜相对体积（体积密度）数据（Daimon等人，1982年）相结合，能够评估胎儿和新生儿细胞质细胞器的平均绝对体积。在妊娠第15天，肝细胞的平均绝对体积为1,523±10.7立方微米。3天后，肝细胞增大了66.2%（2,531.5±108.2），出生时增大了157.1%（3,915.6±190.8）。对每个细胞器的绝对体积和体积密度进行比较，有助于解释肝细胞发育的许多功能和形态学数据。