急性氯喹治疗对前列腺素和促性腺激素刺激的大鼠睾丸睾酮分泌的影响。
Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis.
作者信息
Nduka E U, Dada O A
出版信息
Toxicol Lett. 1984 Dec;23(3):315-20. doi: 10.1016/0378-4274(84)90027-4.
The effect of chloroquine injection to rats on in vitro-testosterone secretion stimulated by human chorionic gonadotropin (hCG) and prostaglandin E1 (PGE1) was studied. Rats were injected for 5 days with chloroquine phosphate. Testosterone secretion was stimulated by hCG or PGE1 for 3 h in the removed testis and was measured by radioimmunoassay. Chloroquine treatment in vivo does not seem to have any demonstrable effect on testosterone secretion stimulated by hCG or PGE 1 in prepubertal as well as in the postpubertal rats. However, in pubertal rats chloroquine treatment inhibited testosterone secretion in hCG-stimulated testis.
研究了氯喹注射液对大鼠的影响，该影响涉及人绒毛膜促性腺激素（hCG）和前列腺素E1（PGE1）刺激的体外睾酮分泌。给大鼠注射磷酸氯喹5天。在摘除的睾丸中，用hCG或PGE1刺激睾酮分泌3小时，并通过放射免疫测定法进行测量。体内氯喹治疗似乎对青春期前和青春期后大鼠中hCG或PGE1刺激的睾酮分泌没有任何明显影响。然而，在青春期大鼠中，氯喹治疗抑制了hCG刺激的睾丸中的睾酮分泌。
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