慢性氯喹治疗对前列腺素和人绒毛膜促性腺激素（hCG）刺激大鼠睾丸分泌睾酮的影响。

Effect of chronic chloroquine treatment on prostaglandin and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat testis.

作者信息

Nduka E U, Dada O A

机构信息

Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria.

出版信息

Andrologia. 1987 Sep-Oct;19(5):561-4. doi: 10.1111/j.1439-0272.1987.tb01900.x.

DOI:10.1111/j.1439-0272.1987.tb01900.x

PMID:3425960

Abstract

The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At the end of the period of treatment, the rats were sacrificed and the Leydig cells incubated with hCG and/or PGE1 for 3 hrs. The amount of testosterone secreted was estimated by radioimmunoassay. Chronic chloroquine treatment did not affect the activity of the Leydig cells and combined PGE1 and hCG did not show any additive effects.

摘要

研究了长期给予氯喹对大鼠睾丸间质细胞中前列腺素E1（PGE1）和人绒毛膜促性腺激素（hCG）刺激睾酮分泌的影响。成年白化（Wistar品系）大鼠每隔一天注射4mg/kg体重的磷酸氯喹，共30天。在治疗期结束时，处死大鼠，将睾丸间质细胞与hCG和/或PGE1一起孵育3小时。通过放射免疫测定法估算分泌的睾酮量。长期氯喹治疗不影响睾丸间质细胞的活性，PGE1和hCG联合使用未显示出任何相加作用。