• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

In vitro-in vivo correlation, a time scaling problem? Evaluation of mean times.

作者信息

Brockmeier D

出版信息

Arzneimittelforschung. 1984;34(11):1604-7.

PMID:6543138
Abstract

A new algorithm for the calculation of the mean time and further statistical moments is presented by means of a mathematical deduction which is outlined in brief. The graphical interpretation of the mathematical results demonstrates that the calculation is easy to perform. Furthermore the method is illustrated in detail with data from a sustained release formulation of theophylline. These data were obtained from a clinical study and from an in vitro dissolution test with the same formulation. Statistical analysis revealed that the rate of release in vivo was slower than in vitro by a factor of 0.7, using a commercial dissolution model. Implications of this approach with respect to in vitro - in vivo correlations are discussed.

摘要

相似文献

1
In vitro-in vivo correlation, a time scaling problem? Evaluation of mean times.
Arzneimittelforschung. 1984;34(11):1604-7.
2
In vitro--in vivo correlation, a time scaling problem? Basic considerations on in vitro dissolution testing.体外-体内相关性，一个时间尺度问题？关于体外溶出度测试的基本思考。
Arzneimittelforschung. 1982;32(3):248-51.
3
In vivo-in vitro correlations with sustained-release theophylline preparations.缓释茶碱制剂的体内-体外相关性
Methods Find Exp Clin Pharmacol. 1984 Oct;6(10):609-18.
4
In vitro--in vivo correlation of dissolution, a time scaling problem? Transformation of in vitro results to the in vivo situation, using theophylline as a practical example.体外-体内溶出相关性：一个时间尺度问题？以茶碱为例，将体外结果转化为体内情况。
Eur J Clin Pharmacol. 1985;28(3):291-300. doi: 10.1007/BF00543326.
5
A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution.一种通过悬浮颗粒的粒度分布预测其溶解行为的新方法。
J Pharm Biomed Anal. 2005 Oct 4;39(5):900-7. doi: 10.1016/j.jpba.2005.05.014. Epub 2005 Jul 14.
6
Modeling accelerated and decelerated drug release in terms of fractional release rate.
Eur J Pharm Sci. 2015 Feb 20;68:51-5. doi: 10.1016/j.ejps.2014.12.003. Epub 2014 Dec 5.
7
[Release, absorption and elimination of theophylline from fast and slowly released oral formulations].[茶碱从速释和缓释口服制剂中的释放、吸收及消除]
Arzneimittelforschung. 1983;33(3):446-52.
8
[The effect of different variables on the in vitro dissolution of a theophylline sustained-release preparation].
Arzneimittelforschung. 1998 May;48(5A):552-6.
9
A new approach to modelling the relationship between in vitro and in vivo drug dissolution/absorption.一种模拟体外和体内药物溶解/吸收之间关系的新方法。
Stat Med. 1999 Jul 30;18(14):1865-76; discussion 1877.
10
In-vitro and in-vivo correlation for two gliclazide extended-release tablets.两种格列齐特缓释片的体外与体内相关性
J Pharm Pharmacol. 2007 Jul;59(7):971-6. doi: 10.1211/jpp.59.7.0009.

引用本文的文献

1
Antibiotic-induced lipopolysaccharide (LPS) release from Salmonella typhi: delay between killing by ceftazidime and imipenem and release of LPS.抗生素诱导伤寒沙门氏菌释放脂多糖（LPS）：头孢他啶和亚胺培南杀菌与LPS释放之间的延迟
Antimicrob Agents Chemother. 1998 Apr;42(4):739-43. doi: 10.1128/AAC.42.4.739.
2
In vitro--in vivo correlation of dissolution, a time scaling problem? Transformation of in vitro results to the in vivo situation, using theophylline as a practical example.体外-体内溶出相关性：一个时间尺度问题？以茶碱为例，将体外结果转化为体内情况。
Eur J Clin Pharmacol. 1985;28(3):291-300. doi: 10.1007/BF00543326.
3
Absorption of glibenclamide from different sites of the gastro-intestinal tract.
格列本脲在胃肠道不同部位的吸收情况。
Eur J Clin Pharmacol. 1985;29(2):193-7. doi: 10.1007/BF00547421.
4
Mean time and first-pass metabolism.
Eur J Clin Pharmacol. 1985;29(1):45-8. doi: 10.1007/BF00547367.
5
The absorption of piretanide from the gastro-intestinal tract is site-dependent.
Eur J Clin Pharmacol. 1986;30(1):79-82. doi: 10.1007/BF00614200.
6
Mean time parameters in pharmacokinetics. Definition, computation and clinical implications (Part II).药代动力学中的平均时间参数。定义、计算及临床意义（第二部分）
Clin Pharmacokinet. 1989 Dec;17(6):424-40. doi: 10.2165/00003088-198917060-00005.
7
Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium.单次口服安乃近钠后，健康受试者体内安乃近代谢物的药代动力学。
Eur J Clin Pharmacol. 1990;38(1):61-5. doi: 10.1007/BF00314805.
8
Pharmacokinetic profile of a novel slow release preparation of molsidomine.莫西多明新型缓释制剂的药代动力学特征
Eur J Clin Pharmacol. 1992;43(3):273-6. doi: 10.1007/BF02333022.