Katz R J, Manik C P
Neuropharmacology. 1984 Dec;23(12A):1425-30. doi: 10.1016/0028-3908(84)90084-4.
Acute exposure to intense (95dB) white noise may selectively increase the open field behavior of rats. Previous studies have indicated that this effect was mediated in part by endogenous opioid neuropeptides. Three experiments were carried out to characterize further and more specifically the stress-activation syndrome, on behavioral and pharmacological grounds. The time course within which blockade of opiates by naltrexone was effective behaviorally was examined. A second experiment examined the issue of cross-tolerance with opiates, by using dependent subjects, while a final experiment examined involvement of enkephalins, by assessing the effects of the drug diprenorphine upon stressed-behavior. Blockade with naltrexone was achieved with a small dose of the drug, and had a behavioral effect restricted to the initial 6 min of a 12-min test. Morphine-dependent rats proved not to be tolerant behaviorally to the activating effect of noise. Finally, diprenorphine did not mimic the effects of naltrexone. It produced no clear changes in the measures at any dose tested.
急性暴露于高强度（95分贝）白噪声可能会选择性地增加大鼠的旷场行为。先前的研究表明，这种效应部分是由内源性阿片肽介导的。进行了三项实验，从行为学和药理学角度进一步更具体地描述应激激活综合征。研究了纳曲酮对阿片类药物的行为阻断有效作用的时间进程。第二项实验通过使用依赖阿片类药物的实验对象研究了与阿片类药物交叉耐受的问题，而最后一项实验通过评估药物二丙诺啡对应激行为的影响研究了脑啡肽的作用。小剂量的纳曲酮即可实现阻断，其行为效应仅限于12分钟测试的最初6分钟。吗啡依赖的大鼠在行为上并未对噪声的激活作用产生耐受。最后，二丙诺啡并未模拟纳曲酮的作用。在任何测试剂量下，它都未使测量指标产生明显变化。
