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Activation of adenylate cyclase by dopamine, GTP, NaF and forskolin in striatal membranes of neonatal, adult and senescent rats.

作者信息

Nomura Y, Makihata J, Segawa T

出版信息

Eur J Pharmacol. 1984 Nov 13;106(2):437-40. doi: 10.1016/0014-2999(84)90736-2.

DOI:10.1016/0014-2999(84)90736-2
PMID:6543337
Abstract

Dopamine (DA) caused a significant activation of striatal adenylate cyclase in neonatal and adult but not in senescent rats. GTP activated cyclase at the adult stage but not at both neonatal and senescent stages. NaF and forskolin activated cyclase at every stage. The coupling mechanism between DA1 receptors and catalytic units of cyclase seems to become functional at the neonatal stage but GTP recognition and/or binding sites lack in stimulatory GTP binding protein in neonatal and senescent membranes.

摘要

相似文献

1
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Eur J Pharmacol. 1984 Nov 13;106(2):437-40. doi: 10.1016/0014-2999(84)90736-2.
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