3-二（羟甲基）氨基-6-（5-硝基-2-呋喃乙烯基）-1,2,4-三嗪对石桥大鼠和Wistar大鼠小肠的致癌作用

Carcinogenic effects of 3-di(hydroxymethyl)-amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine in the small intestine of Ishibashi and Wistar rats.

作者信息

Takahashi M, Nagase S, Takahashi S, Emi Y, Nakae D, Uchida K, Konishi Y

出版信息

Exp Pathol. 1984;26(4):213-9. doi: 10.1016/s0232-1513(84)80052-3.

Abstract

The carcinogenic effect of an oral administration of 3-di(hydroxymethyl)-amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazin e (DHNT) was studied in two strains of rats. Ishibashi (IS) rats have a perpetual absorption disturbance while Wistar Imamichi (WI) rats have no such disturbance. Small intestinal carcinomas developed in 10 out of 15 (66.7%) IS rats and in all 8 (100%) Wistar rats given 3,500 ppm DHNT for 43 weeks. The total number of lesions in the small intestine was 24 in IS rats and 21 in WI rats. Histologically, the lesions consisted of 7 mucosal dysplasias, 4 adenomas and 12 tubular and 1 papillary adenocarcinoma in IS rats, and 3 mucosal dysplasias, 1 adenomas, and 15 tubular and 2 papillary adenocarcinomas in WI rats. The levels of plasma leucine aminopeptidase, copper and total protein were lower, while blood urea nitrogen was higher in both strains of rats given DHNT than in control rats.

摘要

在两种品系的大鼠中研究了口服3 - 二（羟甲基）氨基 - 6 - （5 - 硝基 - 2 - 呋喃乙烯基）-1,2,4 - 三嗪（DHNT）的致癌作用。石桥（IS）大鼠存在永久性吸收障碍，而Wistar Imamichi（WI）大鼠没有这种障碍。给15只IS大鼠中的10只（66.7%）和所有8只Wistar大鼠喂食3500 ppm的DHNT，持续43周，结果IS大鼠中有小肠癌发生，Wistar大鼠全部发生小肠癌。IS大鼠小肠病变总数为24个，WI大鼠为21个。组织学检查显示，IS大鼠的病变包括7个黏膜发育异常、4个腺瘤、12个管状腺癌和1个乳头状腺癌，WI大鼠的病变包括3个黏膜发育异常、1个腺瘤、15个管状腺癌和2个乳头状腺癌。给予DHNT的两种品系大鼠的血浆亮氨酸氨基肽酶、铜和总蛋白水平均低于对照大鼠，而血尿素氮水平高于对照大鼠。