Bensman A, Dardenne M, Murnaghan K, Vasmant D, Bach J F
Int J Pediatr Nephrol. 1984 Dec;5(4):201-4.
In 36 children with nephrotic syndrome (NS) a significant decrease of their serum levels of the thymic-hormone--thymulin--was found, in parallel with a diminution of their mean blood zinc levels as compared to 33 control children. The serum level of thymulin normalized after the in vitro addition of ZnCl2. Similar results have previously been reported in mice subjected to a long term zinc deficient diet. It can therefore be assumed that the decreased biological activity of the thymic hormone noted in NS is secondary to a low serum zinc level. These data could explain certain anomalies of T lymphocytes described in childhood NS.
在36名肾病综合征（NS）患儿中，发现其血清胸腺激素——胸腺素水平显著降低，同时与33名对照儿童相比，其平均血锌水平也有所下降。体外添加氯化锌后，胸腺素血清水平恢复正常。此前在长期缺锌饮食的小鼠中也报道过类似结果。因此可以推测，NS中所观察到的胸腺激素生物活性降低是血清锌水平低所致。这些数据可以解释儿童NS中所描述的某些T淋巴细胞异常情况。
