Tasker R A, Vander Velden P L, Nakatsu K
Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):747-50. doi: 10.1016/0278-5846(84)90051-4.
Dose-response curves were constructed for duration of significant catalepsy in male Sprague-Dawley rats following i.p. administration of four established and two novel narcotic analgesics. The relative potency of the six drugs was levorphanol greater than monacetylmorphine greater than diacetylmorphine greater than dibutanoylmorphine greater than morphine greater than meperidine. Cataleptic potency correlated with analgesic potency for morphine, diacetylmorphine, and dibutanoylmorphine but not for monoacetylmorphine.
在雄性斯普拉格-道利大鼠腹腔注射四种已确定的和两种新型麻醉性镇痛药后，构建了显著僵住症持续时间的剂量反应曲线。六种药物的相对效价为：左啡诺＞单乙酰吗啡＞二乙酰吗啡＞二丁酰吗啡＞吗啡＞哌替啶。吗啡、二乙酰吗啡和二丁酰吗啡的僵住症效价与镇痛效价相关，但单乙酰吗啡则不然。
