Iso H
Yakubutsu Seishin Kodo. 1984 Nov;4(3):243-8.
The effects of post withdrawal periods over a range of 0 to 48 hours on avoidance learning in physically alcohol-dependent rats were examined in a shuttle-box situation. Liquid diet containing 5% ethyl alcohol was withdrawn after 15 days. The severity of the alcohol withdrawal syndrome in rats changed with time elapsed after withdrawal. Severe withdrawal syndrome such as increase in failure to escape from shock due to convulsion, increase in intertrial responses due to hyperactivity, and death appeared when the test was started 4.5 hours after withdrawal. On the other hand, avoidance learning was reduced almost zero within 24 hours, but it recovered to a normal level 48 hours after withdrawal of alcohol.
在穿梭箱实验中，研究了撤酒后0至48小时这段时间对身体依赖酒精的大鼠回避学习的影响。15天后停止给予含5%乙醇的液体饲料。大鼠酒精戒断综合征的严重程度随撤酒后时间的推移而变化。撤酒后4.5小时开始测试时，出现严重的戒断综合征，如因惊厥导致逃避电击失败增加、因多动导致试次间反应增加以及死亡。另一方面，回避学习在24小时内几乎降至零，但在撤酒后48小时恢复到正常水平。
