氟苯丙胺对小鼠阿扑吗啡诱导的笼内攀爬行为及甲基苯丙胺刻板行为的拮抗作用。

Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.

作者信息

Gada V P, Joshi V V, Balsara J J, Chandorkar A G

出版信息

Indian J Physiol Pharmacol. 1984 Oct-Dec;28(4):326-30.

Abstract

Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.

摘要

已发现，以能引发头部抽搐的剂量腹腔注射芬氟拉明（5毫克/千克和10毫克/千克），可拮抗阿扑吗啡诱发的小鼠笼内攀爬行为以及甲基苯丙胺引起的刻板行为。由于芬氟拉明（5毫克/千克和10毫克/千克）不会诱发僵住症，这表明芬氟拉明缺乏突触后纹状体和中脑边缘多巴胺受体阻断活性，芬氟拉明引起的中枢5-羟色胺神经元传递增强可能是其对阿扑吗啡诱发的攀爬行为和甲基苯丙胺刻板行为产生拮抗作用的原因。