Müller W A, Wallner B
Z Orthop Ihre Grenzgeb. 1978;116(2):234-9.
224Ra is used within the therapy of rheumatoid arthritis. The distribution of this radionuclide in the organism was investigated up to 7 days after incorporation in order to estimate a possible risk of late effects. In the autoradiographs we found strong blackenings at those bonesurfaces which faced the injected knee-joint hole. In addition the radionuclide was deposited in skeletal growth-zones similarly as after i.v. and i.p. injections. The dosimetric data (particularly of knee-joint and skeleton) were calculated and compared with those which occur after the therapy of ankylosing spondylitis using i.v. 224Ra injections.
224镭用于类风湿性关节炎的治疗。在注入后长达7天的时间里，对这种放射性核素在生物体内的分布进行了研究，以评估可能存在的迟发效应风险。在放射自显影片中，我们在面向注射膝关节孔的骨表面发现了强烈的变黑现象。此外，该放射性核素在骨骼生长区的沉积情况与静脉内和腹腔内注射后的情况类似。计算了剂量学数据（特别是膝关节和骨骼的），并与使用静脉内注射224镭治疗强直性脊柱炎后出现的数据进行了比较。
