Aubert C, Rouge F
Med Oncol Tumor Pharmacother. 1984;1(3):195-9. doi: 10.1007/BF02934141.
We report the effects of one cytostatic and one anti-emetic, DTIC and chlorpromazine (CPZ), on eight established human melanocyte cell lines using 3 methods of evaluation. Considerable differences in chemo-sensitivity to DTIC were discovered. Both inhibition, stimulation and no effect were seen. CPZ always showed cytotoxic effect in vitro. DTIC combined with CPZ had an antagonistic effect except for one cell line which was synergistic. From the chemosensitivity obtained with a primary tumor, it was impossible to predict that of its metastasis. Two similar metabolic effects in vitro were not necessarily related to identical therapeutic sensitivity in vivo. At least 3 significant results must be obtained in vitro to predict a therapeutic schedule.
我们报告了一种细胞抑制剂（达卡巴嗪，DTIC）和一种止吐药（氯丙嗪，CPZ）对8种已建立的人黑素细胞系的影响，采用了3种评估方法。发现对DTIC的化疗敏感性存在显著差异。观察到既有抑制作用、刺激作用，也有无效的情况。CPZ在体外总是表现出细胞毒性作用。DTIC与CPZ联合使用除了一个细胞系表现为协同作用外，其他均有拮抗作用。从原发性肿瘤获得的化疗敏感性无法预测其转移灶的化疗敏感性。体外两种相似的代谢效应不一定与体内相同的治疗敏感性相关。在体外至少必须获得3个显著结果才能预测治疗方案。
