Ehrenberg L
IARC Sci Publ. 1984(59):107-14.
To a large extent, initiators of current cancer incidence are unknown. This is due partly to lack of proper variables and low statistical power of epidemiological studies and to difficulties of risk estimation from experimental data. Considering these facts, as well as long latent times of genotoxic effects, monitoring systems aiming at risk prevention should: (1) respond soon after onset of exposure; (2) have sufficiently high power; (3) identify causative agents; and (4) permit risk quantitation. The determination of in-vivo adducts to DNA (the target in most genotoxic effects) and, especially, to blood proteins, fulfils these criteria, since the demonstration of protein adducts is a relevant measure of formation of the corresponding DNA adducts.
在很大程度上，目前癌症发病率的引发因素尚不清楚。部分原因在于缺乏合适的变量以及流行病学研究的统计效力较低，还在于从实验数据进行风险估计存在困难。考虑到这些事实，以及遗传毒性效应的长潜伏期，旨在预防风险的监测系统应：（1）在接触开始后迅速做出反应；（2）具有足够高的效力；（3）识别致病因子；（4）允许进行风险定量。测定体内DNA加合物（大多数遗传毒性效应的靶点），尤其是血液蛋白质中的加合物，符合这些标准，因为蛋白质加合物的证明是相应DNA加合物形成的相关指标。
