Karasek M, Bartke A, Doherty P C
J Pineal Res. 1984;1(3):237-44. doi: 10.1111/j.1600-079x.1984.tb00215.x.
The influence on the ultrastructure of pinealocytes of long-term hyperprolactinemia caused by ectopic pituitary transplants and of suppression of prolactin release by bromocriptine was examined morphometrically in male rats. Hyperprolactinemia resulted in an increase in the relative volumes of granular endoplasmic reticulum, vacuoles containing a flocculent material, mitochondria, and lipid droplets. Treatment of grafted rats with bromocriptine reversed the effects of hyperprolactinemia. However, bromocriptine had no apparent influence on the pinealocytes of intact rats. The effects of hyperprolactinemia on the ependymallike secretory process in the pinealocyte were especially pronounced.
通过形态计量学方法，研究了异位垂体移植所致长期高催乳素血症以及溴隐亭抑制催乳素释放对雄性大鼠松果体细胞超微结构的影响。高催乳素血症导致粗面内质网、含有絮状物质的液泡、线粒体和脂滴的相对体积增加。用溴隐亭治疗移植大鼠可逆转高催乳素血症的影响。然而，溴隐亭对未移植大鼠的松果体细胞没有明显影响。高催乳素血症对松果体细胞中类似室管膜的分泌过程的影响尤为显著。
