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乙醇和乙醛对Wistar大鼠血液某些生化参数的影响。

Effects of ethyl alcohol and acetaldehyde on certain biochemical parameters of blood in Wistar rats.

作者信息

Kukiełka E

出版信息

Acta Physiol Pol. 1984 Jul-Aug;35(4):366-72.

PMID:6545930
Abstract

Ethyl alcohol injected intraperitoneally to rats in a dose of 3 g/kg of body weight caused hypoglycaemia which was not observed after similar administration of acetaldehyde in a dose od 0.3 g/kg. The serum levels of lipids and total cholesterol were unchanged after administration of ethyl alcohol while acetaldehyde decreased to cholesterol level 0.5, 1.5 and 3 hours after administration. Both these compounds raised the serum activity of AspAT and AlAT, and this rise was observed 0.5 hour after ethyl alcohol and 6 hours after acetaldehyde.

摘要

以3克/千克体重的剂量腹腔注射给大鼠的乙醇会导致低血糖,而以0.3克/千克的剂量腹腔注射类似剂量的乙醛后则未观察到这种情况。给予乙醇后,血清脂质和总胆固醇水平未发生变化,而给予乙醛后,给药后0.5小时、1.5小时和3小时胆固醇水平下降。这两种化合物都会提高天冬氨酸氨基转移酶(AspAT)和丙氨酸氨基转移酶(AlAT)的血清活性,乙醇给药后0.5小时以及乙醛给药后6小时观察到了这种升高。

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