Overholser K A, Bateman J M, Bamford B R, Harris T R
Microcirc Endothelium Lymphatics. 1984 Jun;1(3):347-63.
In order to see if changes in hemodynamic resistance following reperfusion of ischemic myocardium could be related to alterations in microvascular exchange, we measured resistance (R), permeability surface-area for sucrose (PS), and distribution volumes for tritiated water (V) and for sucrose (VS) in nine anesthetized dogs in which blood to the left anterior descending coronary artery was supplied via a shunt from the carotid artery. Measurements were made during four periods: baseline, reduced coronary artery flow, reperfusion, and a second period of reduced flow. Increase in resistance following reperfusion (R2 = 1.8 +/- 3, R4 = 2.5 +/- .5 mmHg/min/ml, mean +/- s.e.m.) was significantly greater than in nine control dogs in which reperfusion was omitted. Also, the series of interventions including reperfusion lowered PS and V (PS4/PS1 = .54 +/- .07, V4/V1 = .58 +/- .08). Our results suggest that increases in resistance due to reperfusion may be accompanied by a loss in functioning capillary surface area.
为了探究缺血心肌再灌注后血流动力学阻力的变化是否与微血管交换的改变有关，我们对9只麻醉犬进行了测量，这些犬的左前降支冠状动脉血液通过颈动脉分流供应。测量在四个阶段进行：基线期、冠状动脉血流减少期、再灌注期和第二个血流减少期。再灌注后阻力增加（R2 = 1.8 +/- 3，R4 = 2.5 +/- .5 mmHg/min/ml，平均值 +/- 标准误）显著大于9只未进行再灌注的对照犬。此外，包括再灌注在内的一系列干预降低了PS和V（PS4/PS1 = .54 +/- .07，V4/V1 = .58 +/- .08）。我们的结果表明，再灌注引起的阻力增加可能伴随着功能性毛细血管表面积的丧失。
