Peterson H I, Appelgren L, Alpsten M, Karlsson L, Kullberg A B, Mattsson J, Selander D
Microcirc Endothelium Lymphatics. 1984 Aug;1(4):491-507.
The intratumor distribution of the capillary permeability surface area product (PS) correlated to the intratumor distribution of vascular space and of blood flow was studied by labeled albumin in a transplantable rat fibrosarcoma. A wide heterogeneity in intratumor distribution of PS was found. The tumor PS values were not significantly correlated to tumor vascular space or to blood flow values. This might suggest that intravascularly administered drugs could reach a comparative high intratissue concentration also in less vascularized tumor areas.
通过在可移植大鼠纤维肉瘤中使用标记白蛋白，研究了毛细血管通透性表面积乘积（PS）的肿瘤内分布与血管空间和血流的肿瘤内分布之间的相关性。发现PS的肿瘤内分布存在广泛的异质性。肿瘤PS值与肿瘤血管空间或血流值无显著相关性。这可能表明，血管内给药的药物在血管化程度较低的肿瘤区域也能达到相对较高的组织内浓度。
