Lymphomatoid granulomatosis. Successful treatment with CHOP combination chemotherapy.

A patient with lymphomatoid granulomatosis is reported. The patient was treated with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisone as initial management immediately after diagnosis. She obtained a complete remission and remains free of disease 3 1/2 years from the time of diagnosis. The favorable outcome in this patient may be related to her initial limited disease or to the use of initial intensive chemotherapy; nonetheless, the generally unfavorable prognosis of this disease appears to mandate early trials of intensive therapy in most patients.