Cangir A, Ragab A H, Steuber P, Land V J, Berry D H, Krischer J P
Med Pediatr Oncol. 1984;12(1):1-3. doi: 10.1002/mpo.2950120103.
Seventy-three patients under 18 years of age with a recurrent central nervous system tumor were randomized to receive combination chemotherapy with MOPP or OPP. Patients were stratified according to the tumor type into four major disease categories: (1) medulloblastoma, (2) astrocytoma and other glioma, (3) ependymoma, and (4) miscellaneous tumors to provide equal distribution of patients for each treatment within each disease category. Evaluation of response was based on computerized brain scan findings. Thirty-five patients received MOPP and 38 received OPP treatment. There were three complete and six partial remissions among patients receiving MOPP and one complete and five partial remissions among patients receiving OPP. In addition, six patients on MOPP had stable disease for seven to 21 months. Only two patients on OPP had stable disease(6 and 36 months). Most of responses in both treatment regimens occurred in patients with medulloblastoma and astrocytoma. Median duration of remission was nine months for the MOPP and 11 months for the OPP. Two patients on MOPP regimen had fatal myelosuppression. Although the more toxic MOPP regimen produced more responses than OPP in children, differences in the duration of response or survival were not statistically significant (P = .79 and P = .84, respectively).
73名18岁以下复发性中枢神经系统肿瘤患者被随机分为两组，分别接受MOPP或OPP联合化疗。患者根据肿瘤类型被分为四大类疾病：(1)髓母细胞瘤，(2)星形细胞瘤和其他胶质瘤，(3)室管膜瘤，(4)其他肿瘤，以便在每个疾病类别中为每种治疗方法均匀分配患者。疗效评估基于脑部计算机扫描结果。35名患者接受MOPP治疗，38名患者接受OPP治疗。接受MOPP治疗的患者中有3例完全缓解和6例部分缓解，接受OPP治疗的患者中有1例完全缓解和5例部分缓解。此外，6名接受MOPP治疗的患者病情稳定7至21个月。只有2名接受OPP治疗的患者病情稳定(6个月和36个月)。两种治疗方案的大多数缓解都发生在髓母细胞瘤和星形细胞瘤患者中。MOPP治疗组的中位缓解期为9个月，OPP治疗组为11个月。2名接受MOPP方案治疗的患者出现致命性骨髓抑制。虽然毒性更强的MOPP方案在儿童中产生的缓解比OPP更多，但缓解持续时间或生存率的差异无统计学意义(P分别为0.79和0.84)。
