Goncharov N P, Komor A, Pachalia N A, Simarina A I, Ponsold K, Grosse P, Oettel M, Strecke J, Schubert K
Zentralbl Gynakol. 1978;100(5):263-72.
With the substance STS 456, an estrogenic active steroid, a high fertility inhibition could be obtained in the pavian, when administered p. o. over a 5 day period postcoital. The effectiveness and also the side effects were dose dependent. The antifertility mechanism is based on an luteolytic effect, demonstrated by analytical hormonal investigations. The inhibition of the synthesis of steroids in the ovary affected not only progesterone but also the estrogens.
使用雌激素活性类固醇物质STS 456，在禽类交配后口服给药5天，可实现高度的生育抑制。其有效性和副作用均呈剂量依赖性。抗生育机制基于黄体溶解作用，这已通过激素分析研究得到证实。卵巢中类固醇合成的抑制不仅影响孕酮，还影响雌激素。
