患有神经管缺陷的小鼠（卷尾）羊水甲胎蛋白水平。
Levels of alpha-fetoprotein in amniotic fluids of mice (curly-tail) with neural tube defects.
作者信息
Adinolfi M, Beck S, Embury S, Polani P E, Seller M J
出版信息
J Med Genet. 1976 Dec;13(6):511-3. doi: 10.1136/jmg.13.6.511.
Abstract
Mutant curly-tail mice are genetically predisposed to produce offspring with neural tube defects. Estimation of alpha-fetoprotein in the amniotic fluid of fetuses of these mutants has shown that the levels are raised in fetuses with exencephaly and open spina bifida. This suggests that these mice are a valid model for studies of the aetiology and genesis of neural tube defects in man.
摘要
突变卷尾小鼠在遗传上易生出患有神经管缺陷的后代。对这些突变体胎儿羊水甲胎蛋白的评估表明，无脑儿和开放性脊柱裂胎儿的甲胎蛋白水平升高。这表明这些小鼠是研究人类神经管缺陷病因学和发病机制的有效模型。
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