N，N-二甲基甲酰胺二新戊基乙缩醛在固相肽合成中作为对烷氧基苄酯用于高效锚定Nα-9-芴甲氧羰基氨基酸的应用
Application of N,N-dimethylformamide dineopentyl acetal for efficient anchoring of N alpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis.
作者信息
Albericio F, Barany G
出版信息
Int J Pept Protein Res. 1984 Apr;23(4):342-9. doi: 10.1111/j.1399-3011.1984.tb02729.x.
Abstract
The attachment of Fmoc-amino acids onto p- alkoxybenzyl alcohol resins via DCC-DMAP coupling suffers from two different problems: formation of dimers and racemization. The use of N,N-dimethylformamide dineopentyl acetal for the preparation of Fmoc- aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.
摘要
通过二环己基碳二亚胺-4-二甲氨基吡啶偶联将芴甲氧羰基氨基酸连接到对烷氧基苄醇树脂上存在两个不同的问题：二聚体的形成和消旋化。使用N，N-二甲基甲酰胺二新戊基缩醛制备芴甲氧羰基-氨酰氧基苄基连接臂是一种安全有效的锚定方法的基础，该方法可以避免这两个问题。
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