Maly P, Fex G
Acta Radiol Diagn (Stockh). 1984;25(1):65-71. doi: 10.1177/028418518402500113.
Forty anaesthetized rabbits were injected subarachnoidally with equimolal doses, 0.48 mmol/kg body weight (= 185 mg I/kg), of iohexol and metrizamide, administered in solutions iso- and hyperosmolal to the CSF. Concentrations of Na, K, Ca and Mg in the CSF were determined before and 3 hours after the contrast medium injections. Iso-osmolal iohexol caused a uniform decrease in all four cations, which was believed to be a simple dilution. The hyperosmolal solution of iohexol caused a significant relative increase in Ca compared with Na, K and Mg. Both metrizamide solutions caused an increase in Ca over its pre-injection level and a significant relative increase of both Ca and Mg as compared with Na and K. The changes caused by the three latter solutions were consistent with an increase in the blood-brain barrier permeability.
将40只麻醉兔蛛网膜下腔注射等摩尔剂量（0.48 mmol/kg体重 = 185 mg碘/千克）的碘海醇和甲泛葡胺，分别溶于与脑脊液等渗和高渗的溶液中。在注射造影剂前及注射后3小时测定脑脊液中钠、钾、钙和镁的浓度。等渗碘海醇使所有四种阳离子均出现均匀下降，这被认为是单纯的稀释作用。与钠、钾和镁相比，高渗碘海醇溶液使钙显著相对增加。两种甲泛葡胺溶液均使钙高于注射前水平增加，且与钠和钾相比，钙和镁均显著相对增加。后三种溶液引起的变化与血脑屏障通透性增加一致。
