人类大脑中多种毒蕈碱受体亚型的证据。
Evidence for multiple muscarinic receptor subtypes in human brain.
作者信息
Garvey J M, Rossor M, Iversen L L
出版信息
J Neurochem. 1984 Aug;43(2):299-302. doi: 10.1111/j.1471-4159.1984.tb00900.x.
Abstract
Pirenzepine, a compound with selective antimuscarinic activity, was used to distinguish muscarinic acetylcholine receptor subtypes in normal human brain. Hill coefficients and IC50 values derived from the inhibition of specific [3H]L-quinuclidinyl benzilate receptor binding suggest the presence of two muscarinic binding sites, differing both in affinity for pirenzepine and in tissue distribution.
摘要
哌仑西平是一种具有选择性抗毒蕈碱活性的化合物，被用于区分正常人脑中的毒蕈碱型乙酰胆碱受体亚型。从特异性[³H]东莨菪碱受体结合抑制实验得出的希尔系数和IC50值表明存在两个毒蕈碱结合位点，它们对哌仑西平的亲和力和组织分布均不同。
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