Radulesku G G, Kolygin B A
Vopr Onkol. 1984;30(6):33-7.
The effectiveness of a new procedure of inductive polychemotherapy (vincristine, cyclophosphamide, adriamycin and prednisolone) was studied in 60 non-pretreated cases of pediatric non-Hodgkin's lymphoma. The treatment was given in 7-day courses. Remission was registered in 46 out of 60 patients (76.6%). Complete regression of symptoms was observed in 58.3%. A three-year survival rate in the entire study group was 28%; the highest rate (39%) was recorded in abdominal involvement group. Due to slight toxicity the scheme should be recommended for a large-scale integration with practice.
对60例未经预处理的儿童非霍奇金淋巴瘤患者研究了一种新的诱导多药化疗方案(长春新碱、环磷酰胺、阿霉素和泼尼松龙)的疗效。治疗以7天疗程进行。60例患者中有46例(76.6%)实现缓解。58.3%观察到症状完全消退。整个研究组的三年生存率为28%;腹部受累组的生存率最高(39%)。由于毒性轻微,该方案应推荐大规模应用于实际治疗。