Fanciullacci M, Cangi F, Gatto G, Boccuni M, Pietrini U
Experientia. 1984 Jul 15;40(7):731-3. doi: 10.1007/BF01949747.
In 7 healthy volunteers 4% morphine eye-drops, when administered to one eye, caused a miosis limited to that eye. In 7 other healthy volunteers morphine was administered into one eye after bilateral instillation of 0.5% homatropine ophthalmic drops; the eye treated with morphine and homatropine showed a mydriasis less intense than the other eye treated only with homatropine. It is suggested that topical morphine locally affects sympathetic function by inhibiting noradrenaline release into the iris neuromuscular junction.
在7名健康志愿者中，向一只眼睛滴入4%的吗啡滴眼液后，仅该只眼睛出现瞳孔缩小。在另外7名健康志愿者中，双侧滴入0.5%后马托品滴眼液后，再向一只眼睛注入吗啡；用吗啡和后马托品治疗的眼睛，其瞳孔散大程度低于仅用后马托品治疗的另一只眼睛。提示局部应用吗啡通过抑制去甲肾上腺素释放至虹膜神经肌肉接头而局部影响交感神经功能。
