Bukin Iu V, Pozniakov S P
Biull Eksp Biol Med. 1984 Jul;98(7):65-8.
It has been shown that in rats with alimentary hypovitaminosis A, with a sufficiently pronounced decrease in the content of free retinol in blood serum (below 140 ng/ml) and in the liver tissue (below 360 ng/g), there is a complete regression of Pliss's lymphosarcoma. Under the conditions indicated, retinoic acid, in contradistinction to retinol, does not promote the tumor growth. A relative and absolute reduction in blood plasma of the essential amino acids, arginine, methionine and lysine, might be one of the reasons for tumor regression under hypovitaminosis A.
研究表明，在患有营养性维生素A缺乏症的大鼠中，当血清中游离视黄醇含量（低于140 ng/ml）和肝组织中游离视黄醇含量（低于360 ng/g）显著降低时，普利斯氏淋巴肉瘤会完全消退。在上述条件下，与视黄醇不同，视黄酸不会促进肿瘤生长。血浆中必需氨基酸精氨酸、蛋氨酸和赖氨酸的相对和绝对减少，可能是维生素A缺乏症时肿瘤消退的原因之一。
