Horner K C, Bock G R
Brain Res. 1984 Jul;317(1):33-43. doi: 10.1016/0165-3806(84)90137-8.
We have investigated the single unit response in the inferior colliculus of the mouse to electrical pulse stimulation at the auditory periphery. The experimental animals were deafness mutant mice (dn/dn), which have hereditary congenital peripheral pathology. The control animals were normal littermates (+/dn). Monopolar electrical pulses were applied either to the modiolus or the round window and the evoked single unit activity was recorded in the contralateral inferior colliculus (IC). Two types of single unit response were observed: a single-spike response, and a multiple-spike response. There was a predominance of the former in the control animals and of the latter in the mutants. For both modes of stimulation the group mean threshold of response was lower in mutants compared to controls, whilst the maximum number of evoked spikes per 50 presentations was higher in mutants than control animals. The mutant response pattern was similar to that seen in animals with experimentally induced auditory deprivation. The suitability of the deafness mutant as a model for the investigation of coding strategies for cochlear implants is discussed.
我们研究了小鼠下丘对听觉外周电脉冲刺激的单单位反应。实验动物为耳聋突变小鼠（dn/dn），其具有遗传性先天性外周病理学特征。对照动物为正常同窝小鼠（+/dn）。将单极电脉冲施加于蜗轴或圆窗，并在对侧下丘（IC）记录诱发的单单位活动。观察到两种类型的单单位反应：单峰反应和多峰反应。在对照动物中前者占优势，而在突变体中后者占优势。对于两种刺激模式，突变体的群体平均反应阈值低于对照，而每50次呈现诱发的最大尖峰数在突变体中高于对照动物。突变体的反应模式类似于实验性诱导听觉剥夺的动物中所见的模式。讨论了耳聋突变体作为研究人工耳蜗编码策略模型的适用性。
