McCarthy J T, Barham S S, Kumar R
J Steroid Biochem. 1984 Sep;21(3):253-8. doi: 10.1016/0022-4731(84)90277-2.
When rachitic chicks are given 1,25-dihydroxyvitamin D3 in amounts as low as 50 ng/bird, the appearance of the duodenal mucosa is altered within 2 h of the administration of the hormone. The changes are most readily apparent on scanning electron microscopy and include: a more plump appearance of villi with loss of furrows and pits on their surfaces, elongation of villi and a smoother, more uniform microvillus surface. These changes occur within 2 h of the administration of the hormone and persist for as long as 24 h. The morphological change precedes the increase in calcium absorption induced by 1,25-dihydroxyvitamin D3 in the intestine. These observations suggest that 1,25-dihydroxyvitamin D3 may play an important part in maintenance of the structure of the duodenal mucosa.
当给患佝偻病的雏鸡投喂低至50纳克/只的1,25 - 二羟基维生素D3时，在给予该激素后2小时内，十二指肠黏膜的外观就会发生改变。这些变化在扫描电子显微镜下最为明显，包括：绒毛外观更饱满，表面的沟纹和凹坑消失，绒毛伸长，微绒毛表面更光滑、更均匀。这些变化在给予激素后2小时内出现，并持续长达24小时。形态学变化先于1,25 - 二羟基维生素D3在肠道中诱导的钙吸收增加。这些观察结果表明，1,25 - 二羟基维生素D3可能在维持十二指肠黏膜结构中起重要作用。
